Rebirth is a remake of The Binding of Isaac, which was developed by McMillen and Florian Himsl and released in 2011 as an Adobe Flash application. This platform had limitations and led McMillen to work with Nicalis to produce Rebirth with a more advanced game engine, which in turn enabled the substantial addition of content and gameplay features. Three expansions have been released. Afterbirth and Afterbirth+, in October 2015 and January 2017, respectively, with more game content and gameplay modes; Afterbirth+ also added support for user-created content. The third, Repentance, was released in March 2021.

Similar to the original The Binding of Isaac, the plot is based on the biblical story of the same name and was inspired by McMillen's religious upbringing. The player controls Isaac, a young boy whose mother, convinced that she is doing God's work, strips him of everything and locks him in his room. When Isaac's mother is about to kill him, he escapes to the basement and fights through random, roguelike dungeons. The player defeats monsters, using Isaac's tears as projectiles, and collects items which modify his appearance, attributes, and abilities, potentially creating powerful combinations. Unlike the game's predecessor, Rebirth has a limited multiplayer mode, allowing an additional player in Rebirth, later increased to three additional players in Afterbirth and Afterbirth+. Full local co-op support was added to Repentance, where up to four players are able to play as any of the playable characters. Online co-op support was announced as a future feature in September 2023.

(wikipedia)