When you fight Doc Oc for the last time, save up your Spidey Sense energy. When it gets too full or half-way, let him get close and active it. This will help you defeat him without losing health. Note: If you can get good hits on him when three of his four arms are down, you will take little damage if you are careful.

When facing Doc Ock in the final battle, stand your ground in a corner and let him approach you. When he arrives, beware of his tentacles. Dodge them one by one pressing Circle when Spider- Man's head flashes, then respond to each dodge by pressing Triangle and shooting a web at the Doc's tentacles to bind them to the wall or the ground. When all four tentacles are bound to either the ground or the wall, run towards the Doc by holding L1 then pressing Square, performing an uppercut which sends the Doc in the air. Then, hold and release X and continue to press Square rapidly. When the Doc falls to the ground, continue to perform combos to him by pressing Square, but beware of his tentacles. Doc Ock will use them to throw you repeatedly. Web out of there after one combo and move to another corner and repeat the process until the Doc is defeated.