Line your throw up between the #1 and #3 pins. Do not put any spin on the ball and throw it perfectly (100%-100%). This is the easiest way to get a perfect 300 game.
Line up the target line of your bowler between the center arrow and the arrow either to the left or right of it. Then, throw a straight ball, and you should get an easy strike.

Get a ball with a good amount of hook to it. Bring your throw line to the second arrow to the left, then swing the line over to the middle arrow (the line will look like a slash). Put full spin on the ball, and throw it 100%. This may require a little adjustment.

Get a ball with a good amount of hook to it. Keep your throw line exactly where it is without moving it. Put full spin on the ball, and throw a 100%. If the ball has the correct amount of hook to it, it will hit Brooklyn every time. Brooklyn means that it will hit between the #1 and #2 pins (for a right hander) and the #1 and #3 pins (for a left hander).