Choose Iron Man, War Machine, and Cable as your team, and make sure you choose projectile as their ability. Charge your super meter higher then 3, and press L1 + R1 (default for partner A and B actions). The result should be all three of your team members will use their projectile super move, which will take care of the opposition provided they do not block. Note: An advanced part of this trick is to wait until your opponent uses his partner in battle, then use the attack. The result is devastating.

Choose Juggernaut, Hulk, and Colossus to fight. Get to level 3 or maximum. When you use the hyper combo for all three at once (L1 + R1), Juggernaut should push your opponent's character to the corner. Then Colossus and The Hulk should come down from the sky to finish the job. Sometimes this may fully kill your opponent.