Real-time strategy/action game, set on a earth after a Nuclear War where three factions are in conflict. One group is a race that evolved on the surface and was mutated by the radiation and uses mutant animals in place of technology. Another is a race that developed underground, free from the effects of the radiation, that employs conventional vehicles and weapons. The third is a group of robots.

Several new unit types have been added over previous editions of KKND. There is a selection of scenarios for each side in the conflict and the structure allows you limited choice over which missions to attempt. There is also a mission editor. The game is played on an isometrically-viewed landscape and the gameplay involves resource management and combat.