In Escape the Museum, a devastating earthquake has rocked the foundations of the National Museum of History and players must help Susan Anderson, who was knocked unconscious by falling debris while searching the museum for survivors, escape from the crumbling building to the safety outside. Thwarted by doors blocked with rubble and tripped alarm systems, players wander through the museum's maze of 12 different hunt and find areas and 25 action-packed adventure scenes, using the Wii Remote to uncover hidden exits and save priceless archaeological artifacts. Along the way, players will solve puzzles, consult a map and access hints to help them inch closer to freedom and a joyful reunion with Susan's lost daughter, Caitlin.