Rocket Launcher
PLay Through the game at least three times to get all the weapons available in the game once you clock the game the third time save it then the next time you play you will have a rocket launcher with unlimited ammo and plus you can point it in any direction unlike the rocket launchers from the other Resident Evil games.

The ammo you want
Every time you kill the big guy from Resident Evil 2 he will usualy drop ammo. The way to get the best ammo is to kill him with certain types of ammo. Let me explain, if you kill him with the handgun you'll get shotgun ammo so you always get the next best ammo. So, from handgun - shotgun - flame rounds - acid rounds - grenade rounds - magnum ammo.

Weapons

Handgun A: Default weapon. This gun has a decent firing and reloading rate and is useful when trying to conserve ammunition.

Handgun B: Located in the hospital. It has a lightning-fast firing rate but is slightly slow on reload.

Handgun C: Located in the arcade. It holds less ammo than Handgun A but has an improved firing and reload rate.

Handgun D: Found in the library stage. This gun can hold eight shots and has greater shot power. Note: Handguns A through D use the same ammunition.

Shotgun: Located in the prison shower. Very powerful. There is only a limited amount of ammo for it, so use it sparingly.

Grenade Launcher: Located in the underground parking lot of Umbrella HQ. Capable of firing three different rounds (Acid, Flame, Regular grenades). Its ammo is limited, so use it wisely.

Magnum: Located in the factory. More powerful than any other handgun. It has two flaws - it only holds six rounds and is slow to reload.

Rocket Launcher: Best weapon

Fastest sequence
The fastest way to go is Alley 1, Restaurant, Alley 2, Arcade, Sewer, Prison, Roof, Umbrella HQ, Gutter, Rott's house/Cable car, Forest, Mansion/Factory, Heliport.

Death scene selection
Tyrant will kill three different people towards the end of the game, based on where you go in the second street area that leads to the hospital, library, and arcade. Select the arcade to have Tyrant kill the leader of the Umbrella Cleaners. Select the library to have Tyrant kill the mole informant. Select the hospital to have Tyrant kill the man hanging from the helicopter in the opening.

Beat the final boss
When your at the heliport fighting that mutant freak, use A or B to spin. Then while youre spinning use your shotgun (make sure you save ammo). He takes 3 clips and in no time he'll evolve, then do the same thing until his dead.

Easy kills
Aim for the neck/head area for a easier kill and to waste less ammunition.