Call of Juarez is an epic adventure western themed FPS game. The player alternately assumes the roles of two distinct, antagonistic characters: a sneaking fugitive Billy and his hunter the reverend Ray. Apart from the highly interesting, emotional and psychological aspect of the link between the two characters, the player will experience a variety of gameplay with many differences whilst playing a particular character.

The game features fast paced revolver duels using historically accurate firearms, horseback riding, mounted combat and stealth actions in memorable locations set after Western movies. Emergent gameplay based on accurate simulation of not only rigid bodies and rag-dolls but also liquids, gases, fire and smoke makes the gameplay innovative and non-linear.